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Similarities and Differences between Two Modes of Antagonism of the Thyroid Hormone Receptor
Prabodh Sadana, Jong Yeon Hwang, Ramy R. Attia, Leggy A. Arnold, Geoffrey Neale, and R. Kiplin Guy*
ACS Chemical Biology, 2011, 6(10), 1096-106.
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Methylsulfonylnitrobenzoates, a New Class of Irreversible Inhibitors of the Interaction of the Thyroid Hormone Receptor and its Obligate Coactivators That Functionally Antagonizes Thyroid Hormone
Jong Yeo Hwang, Wenwei Huang, Leggy A. Arnold, Ruili Huang, Ramy R. Attia, Michele Connelly, Jennifer Wichterman, Fangy iZhu, Indre Augustinaite, Christopher P. Austin, James Inglese, Ronald L. Johnson and R. Kiplin Guy*
J. Biol Chem. 2011, 286, 11895-908.
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A Quantitative High-Throughput Screen Identifies Novel Inhibitors of the Interaction of Thyroid Receptor β with a Peptide of Steroid Receptor Coactivator 2
Ronald L. Johnson, Jong Yeon Hwang, Leggy A. Arnold, Ruili Huang, Jennifer Wichterman, Indre Augustinaite, Christopher P. Austin, James Inglese, R. Kiplin Guy, and Wenwei Huang
J. Biomol. Screen. 2011, 16, 618-27.
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Improvement of Pharmacological Properties of Irreversible Thyroid Receptor Coactivator Binding Inhibitors
Jong Yeon Hwang, Leggy A. Arnold, Fangyi Zhu, Aaron Kosinski, Thomas J. Mangano, Vincent Setolo, Bryan L. Roth, and R. Kiplin Guy*
J. Med Chem. 2009, 52, 3892-901.
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Structural Insight into the Mode of Action of a Direct Inhibitor of Coregulator Binding to the Thyroid Hormone Receptor
Eva Estébanez-Perpiñá, Leggy A. Arnold, Natalia Jouravel, Marie Togashi, Justin Biethrow, Ellena Mar, Phuong Nguen, Kevin J. Phillips, John D. Baxter, Paul Webb, R. Kiplin Guy, and Robert J. Fletterick*
Mol. Endocrinol. 2007, 21, 2919-28.
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Inhibitors of the Interaction of a Thyroid Hormone Receptor and Coactivators : Preliminary Structure-Activity Relationships
Leggy A. Arnold, Aaron Kosinski, Eva Estébanez-Perpiñá, Robert J. Fletterick, and R. Kiplin Guy*
J. Med. Chem. 2007, 50, 5629-80.
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A High-Throughput Screening Method to Identify Small Molecule Inhibitors of Thyroid Hormone Receptor Coactivator Binding
Leggy A. Arnold*, Eva Estébanez-Perpiñá, Marie Togashi, Anang Shelat, Cory A. Ocasio, Andrea C. McReynolds, Phuong Nguyen, John D. Baxter, Robert J. Fletterick, Paul Webb, and R. Kiplin Guy
Science STKE 2006, 362, pl3.
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Discovery of Small Molecule Inhibitors of the Interaction of the Thyroid Hormone Receptor with Transcriptional Coregulators
Leggy A. Arnold, Eva Estébanez-Perpiñá, Marie Togashi, Natalia Jouravel, Anang Shelat, Andrea C. McReynolds, Ellena Mar, Phuong Nguyen, John D. Baxter, Robert J. Fletterick, Paul Webb and R. Kiplin Guy*
J. Biol. Chem. 2005, 280, 43048-55.
*corresponding author |
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